MiniScanPRO

GMP compliant detection of a variety of radioisotopes

Description

This GMP compliant Thin Layer Chromatography (TLC) scanner can be used for the detection of a variety of radioisotopes.
Equipped with a moving stage and many detectors to choose from, the MiniScanPRO can also be used for data collection and report generation requirements.

Key features

Easy-to-use thanks to automatic positioning
Operate two detectors simultaneously
Modifiable parameters for flexibility
Wide range of detectors available

Detail Information

Your MiniScanPRO TLC Scanner can be monitored via PC and even though the system is compatible with existing chromatography systems, a stand-alone usage is also possible. Variable scan speeds, easy set-up and maintenance as well as the wide range of available detectors are just some of the advantages of this system and facilitate the measurement of most established radioisotopes. Up to two PMT- or PIN diode-based detectors can be used at once. A calibration plate is available upon request.

Technology

MiniScanPRO is a versatile TLC scanner for the detection of radioisotopes on narrow strips and plates. The system is well-suited for routine quality control of ⁶⁸Ga, ¹⁸F (including FDG), ⁹⁹mTc and ¹²³I radiopharmaceuticals as well as most others. MiniScanPRO has two independent channels, one for TLC and one for HPLC, which can be connected to any available detector option.

The TLC strip loaded with the sample is placed on a stage which moves under the fixed radiodetector to record the chromatogram. The second channel can be used for radiodetection in combination with all common HPLC systems. Depending on the nuclide, the optimal detector is selected from a variety of detectors. A combination of radiodetectors, both PIN diode and photomultiplier, etc. may be used for measurements of most radionuclides including ⁶⁸Ga, ¹⁸F, ¹²⁵I, ¹³¹I, ^99mTc, ⁹⁰Y, ¹⁷⁷Lu, ⁶⁴Cu and ¹¹¹In.

Several scan speeds allow detectors to measure a wide range of activities from 10 nCi to 100 μCi (370 Bq – 3.7 MBq) depending on the detector choice. Analog and digital signals are provided for interfacing MiniScanPRO with existing chromatography data systems. The included RaPET Chromatography Software can also be used for your data collection and report generation requirements.

Applications

Routine quality control of ⁶⁸Ga, ¹⁷⁷Lu, ⁹⁰Y, ¹⁸F, ^99mTc, ¹²³I and other radionuclides
TLC of radiopharmaceuticals labeled with gamma, high energy beta and positron emitters for R&D
In-process TLC analysis of reaction mixture
HPLC chromatography of nuclides
Radionuclidic purity assay with optional Multi Channel Analyzer (MCA)

Features and Benefits

Easy-to-use system with flexibility and automatic positioning system
Control via PC
Compatible with existing chromatography systems utilizing analog output of the MiniScanPRO
Wide range of detectors available for various applications
Capable of operating two detectors simultaneously for different applications or in coincidence mode (radio-HPLC mode)
Variable scan speeds
Easy system set-up and maintenance
All parameters, such as threshold (for background, energy window, lower and upper discrimination), high voltage, integration time and plate lenght are accessible and modifiable
Available RaPET-Lab software plugins available for tray movement, measurement and quality control evaluation

MiniScanPRO+ including Multi Channel Analyzer

As an additional feature Eckert & Ziegler offers the MiniScanPRO equipped with a Multi Channel Analyzer (MCA) and the appropriate NaI detector of spectroscopy quality to cover a range of 30 – 1500 keV. The detector is installed inside the device with extra lead shielding.

Recent Publications

2022

Cakici D – Synthesis and Stability Studies of ²²⁵Actinium Tin Colloid Radiopharmaceutical

Background
The growing availability of ready to use cold kits on the market increases the potential of manual handling errors and the risk of high radiation exposure to the operator.
With the KitLab system, Eckert & Ziegler Eurotope GmbH offers an automated solution to improve the reproducibility of results, to protect users from unnecessary exposure and to facilitate synthesis and formulation. The use of defined tools for each kit combined with a fast user setup and easy handling allows a more efficient work schedule and makes the KitLab system very reliable.

Functionality
After connecting the KitLab device to the standard socket outlet, putting the RFID card in place and inserting the cassette, the system is ready for use. For the transfer of liquids KitLab uses the established and well proven peristaltic pump with four independently programmable channels. In addition to performing automated handling of registered kits the device offers the possibility to start a program with time delay function to allow an automatic pre-elution at a scheduled date and time.

Easy data management and storage
The cassettes are delivered with an RFID card that contains important information for the batch report. All data will be gathered via the RFID card reader and the optional barcode scanner and stored on the device itself. The data is combined in one batch report which can be directly printed with the optional label printer. To secure GMP-compliant data storage, batch data are subsequently stored on the internal SD card and additionally on the cassette-specific RFID card. All batch data can be accessed at any time.

Small, sterile and double packed cassettes
All cassettes are assembled under GMP compliant clean room conditions and sterilized with gamma-radiation. They come, depending on the application, with needle-free connections, color coding or V-vials. All features are meant to prevent incorrect use and to facilitate the preparation process. The cassettes are delivered with all further necessary consumables.

Features at a glance

User-friendly application selection via RFID card
Stand-alone device; no PC or EC needed
Very small footprint
Radiation protection – reduction of radiation exposure to the operator (ALARA)
Handling according to registration guidelines, IFU, SmPC
Automated, sterile QC sampling and sterile filtration (optional)
Pre-elution function; delayed start
Automated/controlled elution of generator
Recording/calculation of remaining generator activity
Easy and fail-free insertion of cassette

Adaptable and upgradeable for future use
The KitLab system is intended for the formulation of licensed PET kits. It can furthermore be used for a synthesis with ⁶⁸Ga-HBED-PSMA including pre- and post-purification steps.

Customizable setup
The programming of KitLab is done by Eckert & Ziegler. If you wish to customize your device with a special application or develop liquid transfer processes on you own, check out our Peristaltic Pump Module or get in touch!

Eckert & Ziegler offers a wide range of radiosynthesizers: Modular-Lab Standard is a tubing-based system and has been specifically designed for research and development of radiotracers, whereas Modular-Lab eazy provides a space and cost efficient solution for cassette-based routine production of Theranostics tracers. Modular-Lab PharmTracer also follows the cassette-based approach and can be used for GMP-compliant routine production as well as research purposes.

Downloads

Fact Sheet MiniScanPRO (PDF)

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